Melatonin evidence, 2001

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Zhdanova IV, Wurtman RJ, et al., Journal of Clinical Endocrinology & Metabolism, 2001 — crossover RCT of 0.1–3 mg melatonin in older adults

How to read a grade

Grade
Design
crossover rct
Year
2001
Participants
30
Ingredient
Melatonin
Goal
Sleep

Effect

Doses as low as 0.3 mg improved sleep efficiency comparably to 3 mg; higher doses produced more next-day carryover without better sleep.

Limitations and notes

Why our dose guidance starts at 0.5 mg rather than the retail default of 5–10 mg.

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