Glucosamine + chondroitin evidence, 2006
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Clegg DO, Reda DJ, Harris CL, et al., New England Journal of Medicine, 2006 — GAIT trial of glucosamine and chondroitin for knee discomfort
- Grade
- Design
- rct
- Year
- 2006
- Participants
- 1583
- Ingredient
- Glucosamine + chondroitin
- Goal
- Joint health
Effect
Overall no significant benefit versus placebo; the subgroup with moderate-to-severe knee discomfort reported meaningful improvement on the combination.
Limitations and notes
The honest core of the glucosamine story — we surface the subgroup caveat, not just the headline.